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FAQ: Why should I check my urinary free radical MDA (Malondialdehyde)? 

 

A: BECAUSE IT IS WHAT PROFESSIONAL, PEER REVIEW PUBLISHED RESEARCH USES TO MEASURE THE EFFECTIVENESS OF ANTIOXIDANTS, AND TO MEASURE THE OXIDATIVE STRESS IN THEIR PATIENTS.

The following is a small sampling of a very large body of published research that shows the usefulness of understanding urinary MDA levels in the body, and how they are an excellent guide to nutritional health.

Free Radical test for MDA Malondialdehyde is backed by research.Full Abstracts are at End of List:
1. JOURNAL NAME- Toxicology VOL. 189 NO. 1-2
 July 15th 2003PP. 75-88. 
Research by: Department of Surgery, University of Texas Southwestern Medical Center
Malondialdehyde levels are used in this research as a determining factor of free radical mediated cell injury in burn trauma.

2. JOURNAL NAME- Clinical Biochemistry VOL. 36 NO.
 5 July 2003PP. 397-400. 
Department of Biochemistry, Medical Faculty of
 Istanbul , University of Istanbul , Capa, 34093, Istanbul , Turkey , Turkey
Study was to determine oxidative stress increase in aging. Increased MDA levels was a key determining factor in support of the presence of increased oxidative stress in elderly subjects.

3. JOURNAL NAME- Molecular Medicine (
Baltimore ) VOL. 8 NO. 10 October 2002PP. 581-590. 
Inotek Pharmaceuticals, Suite 419E, 100 Cummings Center, Beverly, MA, 01915, USA
In this study of peroxynitrite as being implicated in the pathogenesis of many inflammatory conditions oxidative stress was a central measurement of the study. MDA was the sole means used to measure oxidative stress.

4. JOURNAL NAME- Gynecologic Oncology VOL. 86 NO.
 3 September, 2002PP. 250-258. 
School of Medicine , University of Extremadur , Avenida Elvas s/n., 06071, Badajoz , Spain
In this study of the effect of ovariectomy, increases in MDA make the determination that uterine oxidative stress is increased.

5. JOURNAL NAME- Clinical Biochemistry VOL. 35 NO.
 4 June, 2002PP. 269-273. 
Department of Clinical Biochemistry, Faculty of Medicine, Kocaeli University of Kocaeli, Kocaeli, Turkey
These findings indicate oxidative stress in patients with chronic renal failure which is further exacerbated by hemodialysis and CAPD, as evidenced by increased lipid peroxidation (MDA) and low antioxidant levels.

6. JOURNAL NAME- Biomedical Research (
Aligarh ) VOL. 12 NO. 3 September-December, 2001 PP. 231-236. 
E-14, GTB Hospital Campus, Dilshad Garden, Delhi, 110095, India
Oxidative stress status was determined by measuring the concentration of urinary malondialdehyde ( MDA ) … Since the measurement of
   MDA in urine gives a 'global' index of the body's oxidative stress status,  our results suggest that there is increased oxidative stress ….

7. JOURNAL NAME- Metabolism VOL. 52 2003 Jul PP. 868-74
Nutrition/Infection Laboratory,
 Beth  Israel Deaconess Medical Center , Harvard Medical School , Boston , MA 02215 , USA .
Levels of malondialdehyde ( MDA ) and total glutathione to were used to assess oxidative stress.

8. JOURNAL NAME- Am J Physiol Renal Physiol VOL. 284 2003 Apr PP. F863-9
Indiana University School of Medicine and Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA.
Oxidative stress to lipids and proteins was measured by an HPLC assay for malondialdehyde (MDA) and carbonyl concentration, respectively.
 “Urinary measurements of markers of oxidative damage to lipids and proteins appear to be more sensitive than plasma measurements in patients with CKD.”

9. JOURNAL NAME- J Appl Toxicol VOL. 22 2002 Sep-Oct PP. 303-9
Department of Biochemistry, The Medical School, Afyon Kocatepe University, Afyon-03200, Turkey.
The oxidative effects of ultraviolet A (UVA) light (320-400 nm) and the antioxidant effects of quercetin were examined. Oxidative stress is reflected by increased MDA and reduced antioxidant enzyme levels.

10. JOURNAL NAME- Am J Physiol Heart Circ Physiol VOL. 282 2002 Apr PP. H1197-205
Department of Physiology and Biophysics, School of Medicine,
 University of Mississippi Medical Center, Jackson , Mississippi 39216 , USA .
Levles of malondialdehyde are described as a marker of oxidative stress.


These ten articles partially scratch the surface of validating the Malondialdehyde (MDA) urine test. Check for yourself. Follow the link PubMed.gov and type "Malondialdehyde urine" in the search box. You will be amazed at the number of research articles for this test!

Abstracts of the above ten journals are available in the following links:

  1. Malondialdehyde
    Malondialdehyde levels are used in this research as a determining factor of free radical mediated cell injury in burn trauma.
  2. Oxidative Stress
    Study was to determine oxidative stress increase in aging. Increased MDA levels was a key determining factor in support of the presence of increased oxidative stress in elderly subjects.
  3. Malondialdehyde Arthritis Colitis
    Malondialdehyde (MDA) was the sole means used to measure oxidative stress in this study.
  4. MDA Oxidative Stress
    In this study of the effect of ovariectomy, increases in MDA make the determination that uterine oxidative stress is increased.
  5. MDA Lipid Peroxidation
    Oxidative stress in patients with chronic renal failure which is further exacerbated by hemodialysis and CAPD, as evidenced by increased lipid peroxidation (MDA) and low antioxidant levels.
  6. Oxidative Stress MDA
    Oxidative stress status was determined by measuring the concentration of urinary malondialdehyde ( MDA ).
  7. Malondialdehyde Oxidative Stress
    Levels of malondialdehyde ( MDA ) and total glutathione to were used to assess oxidative stress.
  8. Oxidative Stress Malondialdehyde
    Urinary measurements of markers of oxidative stress and damage to lipids and proteins appear to be more sensitive than plasma measurements in patients with CKD.
  9. MDA Oxidative Stress
    Oxidative stress is reflected by increased MDA and reduced antioxidant enzyme levels.
  10. Oxidative Stress Malondialdehyde
    Levles of malondialdehyde are described as a marker of oxidative stress.

 

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and products to evaluate your body and water for toxic metals and remove them if necessary.

 


Keith Bishop, Clincal Nutritionist, B.Sc. Pharmacy, Health Coach  

Keith D. Bishop
Clinical Nutritionist
B.Sc. Pharmacy
Health Coach©


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